Long‐Read Next‐Generation Sequencing Technologies Can Address Some Limitations of Short‐Read Technologies in HLA Typing

This case highlights the ability of long-read sequencing to resolve cis-trans ambiguities and improve allele phasing, and to enhance accuracy for new HLA allele identification.

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Publication Details

Journal
International Journal of Immunogenetics
Published
2026-03-14
DOI
https://doi.org/10.1111/iji.70046
Primary Topic
T-cell and B-cell Immunology
Type
article
Field-Weighted Citation Impact
0.00
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article

Long‐Read Next‐Generation Sequencing Technologies Can Address Some Limitations of Short‐Read Technologies in HLA Typing

Nicolas Guillaume, Judith Desoutter, Julien Lion, Marianne Perriere
International Journal of Immunogenetics
T-cell and B-cell Immunology
article

Long‐Read Next‐Generation Sequencing Technologies Can Address Some Limitations of Short‐Read Technologies in HLA Typing

Nicolas Guillaume, Judith Desoutter, Julien Lion, Marianne Perriere
article en

Abstract

This case highlights the ability of long-read sequencing to resolve cis-trans ambiguities and improve allele phasing, and to enhance accuracy for new HLA allele identification.

International Journal of Immunogenetics
Centre Hospitalier Universitaire Amiens-Picardie (FR), Université de Picardie Jules Verne (FR)
Openalex Percentile: Top 21%
T-cell and B-cell Immunology
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