Sinominine alleviates pulmonary fibrosis by suppressing macrophage-to-myofibroblast transition via inhibition of the Frem1/NF-κB/IL-1β axis
Our study unveils a novel mechanism whereby SIN ameliorates pulmonary fibrosis by directly targeting Frem1 to disrupt an IL-1β-driven positive feedback loop and subsequent MMT.
Authors
- Zichao Yu (ORCID: https://orcid.org/0000-0001-6175-5544)
- Muqiu Liu
- H. Ni (ORCID: https://orcid.org/0000-0001-5231-0068)
- Junhui Zheng
- Huaizhi Du
- Yining Guo
- Yan Dong
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Dongguan University of Technology (CN)
- Dongguan People’s Hospital (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2026-03-14
- DOI
- https://doi.org/10.1016/j.intimp.2026.116511
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00