Dengue molecular dynamics: viral load and serotype shifts predict severity and death in Kolkata, Eastern India
The study identifies a 'prevalence-virulence dissociation' where DENV-2 dominates numerically but DENV-3 drives mortality. Quantitative viral load is a robust prognostic marker. Integrating real-time molecular surveillance and Ct threshold into triage protocols is vital for mitigating fatal outcomes in hyperendemic regions.
Authors
- Swagata Ganguly Bhattacharjee (ORCID: https://orcid.org/0000-0002-5978-778X)
- Arup Kumar Pattanayak (ORCID: https://orcid.org/0000-0001-8096-3023)
- Dipankar Maji
- Kaushik Pramanik (ORCID: https://orcid.org/0000-0002-4618-2212)
- Indira Dey (ORCID: https://orcid.org/0000-0003-4184-0295)
- Suman Kundu
Institutions
- Nil Ratan Sircar Medical College and Hospital (IN)
- Salt Lake Regional Medical Center (US)
- ESI - Post Graduate Institute of Medical Science and Research (IN)
Publication Details
- Journal
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1093/trstmh/trag027
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00