Plasmin–PAI-1 Imbalance Contributes to Hyperglycemia-Induced Vascular Calcification
These findings suggest that PAI-1 contributes to hyperglycemia-related VC, whereas plasmin exerts protective effects partly through AMPK-eNOS activation. Modulating plasmin activity or targeting PAI-1 may represent potential therapeutic approaches to prevent VC progression in diabetes.
Authors
- Osamu Matsuo (ORCID: https://orcid.org/0000-0002-9806-2204)
- Yosuke Kanno (ORCID: https://orcid.org/0000-0001-9741-2113)
- Kei-ichi Ozaki
- Moeko Okuno
Publication Details
- Journal
- Journal of Vascular Research
- Published
- 2026-03-14
- DOI
- https://doi.org/10.1159/000551570
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00