Third-generation cryotherapy reduces time to surgery and local complications in patients with ankle fractures: a prospective randomised controlled trial

Preoperative third-generation cryotherapy is effective in reducing time to surgery, preoperative pain, and opioid intake in patients hospitalised for ankle fractures. It is also effective in reducing the occurrence of skin complications. No major complications related to the use of the device were reported. Third-generation cryotherapy is useful in the perioperative management of patients necessitating surgery for ankle fractures. Clinical Trial Registration NCT06396364. Level of evidence I (RCT).

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Publication Details

Journal
Journal of Orthopaedic Surgery and Research
Published
2026-03-14
DOI
https://doi.org/10.1186/s13018-025-06599-x
Primary Topic
Foot and Ankle Surgery
Type
article
Field-Weighted Citation Impact
0.00
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article

Third-generation cryotherapy reduces time to surgery and local complications in patients with ankle fractures: a prospective randomised controlled trial

Riccardo Maria Lanzetti, Stefania De Sanctis, Marco Spoliti, Raffaella Alonzo et al.
Journal of Orthopaedic Surgery and Research
Foot and Ankle Surgery
article

Third-generation cryotherapy reduces time to surgery and local complications in patients with ankle fractures: a prospective randomised controlled trial

Riccardo Maria Lanzetti, Stefania De Sanctis, Marco Spoliti, Raffaella Alonzo, Francesco Anzano, Giovanna Fidone, Carmelo D’arrigo, Gennaro Pipino, Alessio Giai Via, Filippo Migliorini, Nicola Maffulli
article en

Abstract

Preoperative third-generation cryotherapy is effective in reducing time to surgery, preoperative pain, and opioid intake in patients hospitalised for ankle fractures. It is also effective in reducing the occurrence of skin complications. No major complications related to the use of the device were reported. Third-generation cryotherapy is useful in the perioperative management of patients necessitating surgery for ankle fractures. Clinical Trial Registration NCT06396364. Level of evidence I (RCT).

Journal of Orthopaedic Surgery and ResearchVol. 21(1)
Mile End Hospital (GB), San Raffaele University of Rome (IT), Ospedale di Bolzano (IT), Azienda Ospedaliera San Camillo-Forlanini (IT), Ospedale San Paolo (IT), Azienda Ospedaliera Sant'Andrea (IT), IRCCS San Camillo Hospital (IT), Nini Hospital (LB), University Hospital in Halle (DE), Carlo Forlanini Hospital (IT), Villa Torri Hospital (IT), Link Campus University (IT), Martin Luther University Halle-Wittenberg (DE), Sapienza University of Rome (IT)
Good health and well-being
Openalex Percentile: Top 22%
Foot and Ankle Surgery
DOIOpen Access PDFOpenAlex
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Third-generation cryotherapy reduces time to surgery and local complications in patients with ankle fractures: a prospective randomised controlled trial — Riccardo Maria Lanzetti, Stefania De Sanctis, et al. · Journal of Orthopaedic Surgery and Research (2026) | TGRS Research Map | TGRS