Electro‐Mediated Redox Functionalization of Conjugated 1,3‐Dienes

Conjugated 1,3‐dienes are abundant, readily available raw materials and key structural motifs in natural or bioactive molecules. The direct conversion of these versatile building blocks into value‐added products is an attractive area in synthetic chemistry. However, their selective functionalization remains a major challenge due to intrinsic regio‐ and stereoselectivity issues arising from multiple reactive sites. Traditional approaches, mostly involving two‐electron mediated transition‐metal catalysis, have faced challenges and motivated the development of new redox strategies, predominantly based on photocatalytic approaches. In this context, electrosynthesis has recently emerged as a competent and environmentally friendly alternative, allowing the generation of reactive metallic or open‐shelf organic radical intermediates under mild redox conditions. This comprehensive review provides an overview of electro‐mediated transformations of conjugated 1,3‐dienes, with an emphasis on the mechanisms involved. It is organized in three main sections encompassing hydrofunctionalization, two‐component difunctionalization and multicomponent processes.