O-GlcNAcylation of IGF2BP2 promotes angiogenesis after ischemic stroke by stabilizing PPP2CA in an m6A-dependent manner
O-GlcNAcylation of IGF2BP2 reduces its ubiquitination and degradation, thereby stabilizing PPP2CA by m6A modification. Upregulated PPP2CA drives dephosphorylation and nuclear translocation of YAP, which promotes angiogenesis to alleviate the injury after IS.
Authors
- Xu Chen (ORCID: https://orcid.org/0000-0002-2978-262X)
- Yimin Zhu
- Meiyi Tao
- Yongwen Deng
- Shengli Sun
Institutions
- Hunan Normal University (CN)
- Hunan Provincial People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2026-03-14
- DOI
- https://doi.org/10.1186/s12967-026-07854-3
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.00