Dual testing with immunohistochemistry and PCR for enhanced accuracy in dMMR/MSI detection in Greek colorectal cancer population: the impact of retesting
In this retrospective, single-center cohort, dual assessment of MMR status by IHC and PCR was associated with near-perfect inter-method agreement and reduced the likelihood of technical misclassification. These findings support the practical value of reflex retesting as a quality-assurance step within a workflow-oriented diagnostic strategy.
Authors
- Eirini Thymara
- Stratigoula Sakellariou (ORCID: https://orcid.org/0000-0002-3639-6807)
- Antonis Vylliotis
- Alexandros Pergaris (ORCID: https://orcid.org/0000-0002-4960-672X)
- Panagiotis Travlos
- Charalampos Fanariotis
- Andreas C. Lazaris
Institutions
- Hellenic Aerospace Industry (Greece) (GR)
- National and Kapodistrian University of Athens (GR)
Publication Details
- Journal
- Personalized Medicine
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1080/17410541.2026.2644210
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 0.00