FAT4 loss promotes tumor growth and ferroptosis resistance in hepatocellular carcinoma via PI3K/AKT pathway activation
FAT4 may enhance ferroptosis sensitivity in HCC by suppressing GPX4 and SLC7A11 expression, potentially by inhibiting PI3K/AKT signaling. Thus, this study presents FAT4 as a biomarker associated with tumor progression and a potential determinant for overcoming ferroptosis resistance in HCC.
Authors
- Xinfeng Sun
- Wenmin Yang
- Kongli Fan
- Minling Lv
- Jialing Sun
- Mengqing Ma
- Yuan Yang
- Yan Wang
- Jing Li
- Qi Huang
- Rui Hu
- Xiaozhou Zhou
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Shenzhen Pingle Orthopedic Hospital (CN)
Publication Details
- Journal
- Clinical & Translational Oncology
- Published
- 2026-03-14
- DOI
- https://doi.org/10.1007/s12094-026-04302-y
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00