Shenkang Injection Prevents Contrast-Induced Nephropathy byRegulating Ferroptosis Via the STAT3/HIF-1α/HMOX-1 Pathways
The active compound SKI significantly reduced ferroptosis in HK-2 cells induced by CM. This finding suggests that SKI is a potentially effective treatment for CIN by modulating the STAT3/HIF-1α/HMOX-1 signaling pathway.
Authors
- Junle Yang
- Wenting Yuan
- Yongbin Li (ORCID: https://orcid.org/0009-0008-4504-2163)
- Shangguang Kan
- Yang Yang
Institutions
- Northwest University (CN)
- First Hospital of Xi'an (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2026-03-12
- DOI
- https://doi.org/10.2174/0113862073397347251212110054
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00