Velvet bean (Mucuna pruriens L. (DC.)) leaf ointment: candidate for standardized natural anti-inflammatory drug ingredients based on local wisdom

Skin inflammation is a serious problem that must be addressed. The use of steroid and non-steroid drugs is effective as an anti-inflammatory but has many side effects. One of the natural ingredients used by the community as an anti-inflammatory is the leaves of the velvet bean (Mucuna pruriens L. (DC.)). This study aims to prove that velvet bean leaf ointment is effective as an anti-inflammatory, which is indicated by improvements in the morphology and structure of the skin tissue of mice experiencing inflammation. The research method is an experiment with a completely randomized design consisting of 6 treatments with five replications (normal, negative control, positive control, and velvet bean leaf ointment at 200, 400, and 600 mg/kgBW). Quantitative data were analyzed using Duncan's Multiple Range Test. The results showed that the use of ointments of 200 and 400 mg/kgBW was able to improve the morphology of the skin of mice experiencing inflammation, which was indicated by a significant decrease in the thickness of the back folds (P