Mast cell-derived MIF Polarizes Th17 cells to drive lung adenocarcinoma progression
Our findings establish that MCs promote LUAD progression mainly through MIF-mediated polarization of Th17 cells, revealing the MC-MIF-Th17 axis as a promising therapeutic target for LUAD treatment.
Authors
- Qing Peng (ORCID: https://orcid.org/0000-0002-6991-9432)
- Zhengfeng Yang (ORCID: https://orcid.org/0000-0003-2011-9466)
- Xun Xu (ORCID: https://orcid.org/0000-0002-0504-362X)
- Jinghan Song
- Xiong Ye
- Hui Xiao
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Chest Hospital (CN)
- Shanghai First People's Hospital (CN)
- Shanghai University of Medicine and Health Sciences (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2026-03-14
- DOI
- https://doi.org/10.1007/s00262-026-04358-3
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 0.00