Acute myeloid leukemia with thrombocytosis: A paradox explained

Abstract: Acute myeloid leukemia (AML) with thrombocytosis is a rare entity, accounting for approximately 1% of AML cases. A 46-year-old male presented with fever and thrombocytosis, and was ultimately diagnosed with AML characterized by the recurrent genetic abnormality t(3;3)(q23;q23), associated with MECOM (EVI1) rearrangement. Despite induction chemotherapy, the disease course was aggressive with short-lived remissions and rapid progression. This case highlights the diagnostic challenges, prognostic implications, and therapeutic considerations of this rare AML subtype.