An unusual presentation of miliary tuberculosis with medullary nephrocalcinosis in an infant

Miliary tuberculosis (MTB) is a rare and potentially fatal manifestation of <i>Mycobacterium tuberculosis</i> infection, resulting from hematogenous dissemination of the primary infection. Although more commonly seen in immunocompromised individuals, infants are also susceptible due to their immature immune systems. We present the case of an 88-day-old female with MTB and extrapulmonary disease involving the liver, spleen, kidneys, and retina. Imaging demonstrated diffuse pulmonary nodules, hepatic and splenic granulomas, and nephrocalcinosis. This case highlights the hallmark radiologic features seen in MTB and extrapulmonary disease, along with imaging of medullary nephrocalcinosis, a rare extrapulmonary manifestation.

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Publication Details

Journal
Radiology Case Reports
Published
2026-03-14
DOI
https://doi.org/10.1016/j.radcr.2026.02.022
Primary Topic
Diagnosis and treatment of tuberculosis
Type
article
Field-Weighted Citation Impact
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article

An unusual presentation of miliary tuberculosis with medullary nephrocalcinosis in an infant

Eyassu Hailemichael, Dhairya A. Lakhani, Kyle R. Knutsen, Rita Sico
Radiology Case Reports
Diagnosis and treatment of tuberculosis
article

An unusual presentation of miliary tuberculosis with medullary nephrocalcinosis in an infant

Eyassu Hailemichael, Dhairya A. Lakhani, Kyle R. Knutsen, Rita Sico
article en

Abstract

Miliary tuberculosis (MTB) is a rare and potentially fatal manifestation of <i>Mycobacterium tuberculosis</i> infection, resulting from hematogenous dissemination of the primary infection. Although more commonly seen in immunocompromised individuals, infants are also susceptible due to their immature immune systems. We present the case of an 88-day-old female with MTB and extrapulmonary disease involving the liver, spleen, kidneys, and retina. Imaging demonstrated diffuse pulmonary nodules, hepatic and splenic granulomas, and nephrocalcinosis. This case highlights the hallmark radiologic features seen in MTB and extrapulmonary disease, along with imaging of medullary nephrocalcinosis, a rare extrapulmonary manifestation.

Radiology Case ReportsVol. 21(6)
West Virginia University (US), West Virginia University Hospitals (US)
Good health and well-being
Openalex Percentile: Top 22%
Diagnosis and treatment of tuberculosis
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