Poststroke epilepsy is associated with vascular cognitive disorder in young stroke patients: The <scp>ODYSSEY</scp> study
We found independent associations between PSE and major VCD, and between PSE and cognitive impairment in the attention and working memory domain. This could support the "second-hit hypothesis," in which epilepsy following a primary injury relates directly to increased cognitive impairment with a subcortical neuropsychological profile.
Authors
- Frank G. van Rooij (ORCID: https://orcid.org/0000-0002-2411-1915)
- Marian S.G. van Zagten (ORCID: https://orcid.org/0000-0003-1863-4485)
- P. P. De Kort
- Gert W. van Dijk
- Esmée Verburgt (ORCID: https://orcid.org/0000-0001-5563-069X)
- Mijntje M.I. Schellekens (ORCID: https://orcid.org/0000-0001-8757-619X)
- Mayte E. van Alebeek (ORCID: https://orcid.org/0009-0009-0754-3220)
- Tom den Heijer (ORCID: https://orcid.org/0009-0000-5522-2266)
- Sarah E. Vermeer (ORCID: https://orcid.org/0000-0002-1237-1779)
- Renate M. Arntz (ORCID: https://orcid.org/0009-0008-1785-4551)
- Nina A. Hilkens (ORCID: https://orcid.org/0000-0002-7757-6724)
- Inge W.M. van Uden
- KF de Laat
- Frederik J Reitsma (ORCID: https://orcid.org/0009-0004-8406-2715)
- Marieke J H Wermer
- Ido R. van den Wijngaard
- Paul J. A. M. Brouwers
- Anouk van Norden
- Robert J. van Oostenbrugge
- Rob P. W. Rouhl
- Rob A. R. Gons
- Julia H. van Tuijl
- Roy P. C. Kessels
- Frank‐Erik de Leeuw
- Paul J. Nederkoorn
- Jamie I. Verhoeven
- Anil M. Tuladhar
Institutions
- Radboud University Nijmegen (NL)
- Leiden University Medical Center (NL)
- Gelre Hospitals (NL)
- Catharina Ziekenhuis (NL)
- Medisch Spectrum Twente (NL)
- Medisch Centrum Leeuwarden (NL)
- Radboud University Medical Center (NL)
- Maastricht University (NL)
- Sint Franciscus Gasthuis (NL)
- Medisch Centrum Haaglanden (NL)
- Amphia Ziekenhuis (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- Canisius-Wilhelmina Ziekenhuis (NL)
- Vincent Van Gogh Voor Geestelijke Gezondheidszorg (NL)
- Kempenhaeghe (NL)
- Haga Hospital (NL)
- Elisabeth-TweeSteden Ziekenhuis (NL)
- Amsterdam University Medical Centers (NL)
- Rijnstate Hospital (NL)
- Jeroen Bosch Ziekenhuis (NL)
Publication Details
- Journal
- Epilepsia
- Published
- 2026-03-14
- DOI
- https://doi.org/10.1002/epi.70200
- Primary Topic
- Traumatic Brain Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00