Copper‐Bonded Polyoxovanadates‐Based Hybrids as Efficient Catalysts for Azide−Alkyne Cycloaddition

ABSTRACT Constructing structurally well‐defined copper‐based polyoxovanadates (POVs) catalysts for azide–alkyne cycloaddition is an attractive yet challenging research objective. Herein, three copper‐based POVs hybrids, formulated, respectively, as [Cu(dpa)][V 2 O 6 ] ( 1 ), [Cu(bipy)][V 2 O 6 ] ( 2 ), [Cu(phen)(H 2 O)][V 2 O 6 ] ( 3 ) (dpa = 2,2′‐dipyridylamide, bipy = 2,2′‐bipyridine, phen = 1,10‐phenanthroline) were successfully synthesized and fully characterized. Importantly, the three hybrids showed high efficiency for the azide–alkyne cycloaddition under mild conditions, and the yields were up to 99% because they integrate the catalytic ability of Cu sites with the multielectron‐transfer ability of POVs. Moreover, the reusability of 3 was further investigated, and no significant decrease in catalytic activity was observed. These results indicate a sustainable molecular‐level strategy to expand the application of POVs in the azide–alkyne cycloaddition for constructing triazole derivatives.