Study on the Mechanism of Post-Chemotherapy Metastasis in Breast Cancer Based on Metabolomics and Development of TCM Metabolic Regulators
Upregulated phospholipid metabolism is a critical mechanism behind chemotherapy-induced BC metastasis. Combining CMF with phospholipid-targeting agents (idelalisib or EC) offers a promising therapeutic approach to optimize chemotherapy outcomes. These results provide a theoretical foundation for developing novel combination therapies in BC treatment.
Authors
- W Y Wang
- Zhidong Qiu
- Zhe Yu (ORCID: https://orcid.org/0009-0009-1370-6954)
- Ye Qiu (ORCID: https://orcid.org/0000-0001-9182-1952)
- Wanfang Zhu
- Junjie Tao
- Mengyuan Wang
Institutions
- Changchun University of Chinese Medicine (CN)
- The Affiliated Hospital to Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- Anti-Cancer Agents in Medicinal Chemistry
- Published
- 2026-03-12
- DOI
- https://doi.org/10.2174/0118715206433354251202101936
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00