Safety and Tolerability of Oral Islatravir Once Monthly as Pre-Exposure Prophylaxis in Cisgender Men and Transgender Women Who Have an Elevated Likelihood of HIV-1 Exposure: Results From the IMPOWER-24 Randomized Phase 3 Study
Islatravir qm was generally well-tolerated; decreases in total lymphocytes were observed with islatravir. Original primary efficacy objectives were not assessed due to early study stoppage.
Authors
- Javier R. Lama (ORCID: https://orcid.org/0000-0002-4983-5725)
- James B. Brock (ORCID: https://orcid.org/0000-0001-8967-0606)
- Marc Siegel (ORCID: https://orcid.org/0000-0001-9029-8389)
- Brenda Homony
- Peter Sklar (ORCID: https://orcid.org/0009-0000-7071-6942)
- Federico Hinestrosa (ORCID: https://orcid.org/0000-0003-3687-8168)
- Khuanchai Supparatpinyo (ORCID: https://orcid.org/0000-0003-1838-4826)
- Catherine Creticos
- Jose Valdez Madruga
- Shobha Swaminathan (ORCID: https://orcid.org/0000-0001-8609-3073)
- Jiejun Du
- Ronnie M. Gravett (ORCID: https://orcid.org/0000-0002-1614-758X)
- Ravindre Panchia (ORCID: https://orcid.org/0000-0002-3601-0839)
- Johannes Lombaard
- Yvett Pinedo
- Barbara J. Evans (ORCID: https://orcid.org/0000-0001-8115-7971)
- Michael Robertson (ORCID: https://orcid.org/0000-0001-8247-1057)
- Nkosiphile Ndlovu (ORCID: https://orcid.org/0009-0008-3206-9666)
- Cynthia Brinson
- Peggy May T. Hwang
- A Lina Rosengren
- Jean-Michel Molina
- Susan Buchbinder
- Beatriz Grinsztejn
- Anchalee Avihingsanon
- Gordon E Crofoot
- Susanne Doblecki-Lewis
- Igho Ofotokun
- Thanyawee Puthanakit
- Shinichi Oka
- Rebeca M Plank
- Raphael J Landovitz
- Eduard J Sanders
- Geoffroy Liegeon
- Moti N Ramgopal
- Beth Jackson
- Jorge Rodriguez
Institutions
- Rutgers, The State University of New Jersey (US)
- University of North Carolina at Chapel Hill (US)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Howard Brown Health Center (US)
- APLA Health (US)
- University of Miami (US)
- Emory University (US)
- Inserm (FR)
- Chulalongkorn University (TH)
- University of the Witwatersrand (ZA)
- George Washington University (US)
- Université Paris Cité (FR)
- Asociación Civil Impacta Salud y Educación (PE)
- University of Mississippi Medical Center (US)
- University of Alabama at Birmingham (US)
- National Institute of Infectious Diseases (JP)
- National Center for Global Health and Medicine (JP)
- Assistance Publique – Hôpitaux de Paris (FR)
- San Francisco Department of Public Health (US)
- CRO Laboratories (United States) (US)
- Via Libre (PE)
- Centro de Referência em Informação Ambiental (BR)
- HIV Netherlands Australia Thailand Research Collaboration (TH)
- Hôpital Lariboisière (FR)
- Aurum Institute (ZA)
- Orlando Immunology Center (US)
- Clinvet (ZA)
- Global Policy Institute (US)
- Instituto Evandro Chagas (BR)
- Perinatal HIV Research Unit (ZA)
- Central Texas Spine Institute (US)
- Indian River State College (US)
- Chiang Mai University (TH)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1093/cid/ciag171
- Primary Topic
- HIV/AIDS Research and Interventions
- Type
- article
- Field-Weighted Citation Impact
- 0.00