Autologous fat grafting in a case of Parry-Romberg syndrome: a case report

Progressive hemifacial atrophy, also known as Parry-Romberg syndrome (PRS), is an uncommon condition that causes slow and progressive unilateral soft-tissue atrophy of the face. This atrophy affects the skin and subcutaneous tissue, including fat and muscle, and in some cases, may also involve the underlying bone and muscle. The exact cause of this syndrome is unknown, but several possible factors have been suggested. These include genetic predisposition, autoimmune responses, and infections or trauma. We report a case of a young female who presented with an asymptomatic one-sided atrophy of the face for the last ten years. This case highlights autologous fat grafting as a safe and effective option for restoring facial symmetry in PRS.

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Publication Details

Journal
Case Reports in Plastic Surgery and Hand Surgery
Published
2026-03-14
DOI
https://doi.org/10.1080/23320885.2026.2644772
Primary Topic
Systemic Sclerosis and Related Diseases
Type
article
Field-Weighted Citation Impact
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article

Autologous fat grafting in a case of Parry-Romberg syndrome: a case report

Bhushan Madke, Bhakti Sarda, Dr Adarshlata Singh, Sapna Nere
Case Reports in Plastic Surgery and Hand Surgery
Systemic Sclerosis and Related Diseases
article

Autologous fat grafting in a case of Parry-Romberg syndrome: a case report

Bhushan Madke, Bhakti Sarda, Dr Adarshlata Singh, Sapna Nere
article en

Abstract

Progressive hemifacial atrophy, also known as Parry-Romberg syndrome (PRS), is an uncommon condition that causes slow and progressive unilateral soft-tissue atrophy of the face. This atrophy affects the skin and subcutaneous tissue, including fat and muscle, and in some cases, may also involve the underlying bone and muscle. The exact cause of this syndrome is unknown, but several possible factors have been suggested. These include genetic predisposition, autoimmune responses, and infections or trauma. We report a case of a young female who presented with an asymptomatic one-sided atrophy of the face for the last ten years. This case highlights autologous fat grafting as a safe and effective option for restoring facial symmetry in PRS.

Case Reports in Plastic Surgery and Hand SurgeryVol. 13(1)
Datta Meghe Institute of Higher Education and Research (IN)
Openalex Percentile: Top 23%
Systemic Sclerosis and Related Diseases
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