Characterization of efflux pump channel of florfenicol for resistance-enhancing variant RE-CmeABC in <i>Campylobacter</i>
Our findings reveal that the enhanced resistance is primarily due to a functional specialization of the P1 efflux channel in RE-CmeB. This elucidation, strongly supported by the concordance between computational predictions and experimental data, provides a mechanistic basis and high-value targets (Q87/K89) for the development of efflux pump inhibitors against multidrug-resistant Campylobacter.
Authors
- Chang Li (ORCID: https://orcid.org/0000-0002-3267-1859)
- Y. Fan (ORCID: https://orcid.org/0000-0001-7868-3858)
- Wenkai Zhao (ORCID: https://orcid.org/0000-0001-7436-2192)
- Mengguo Chen
- Cheng Zhang (ORCID: https://orcid.org/0009-0004-6093-7265)
- Shun Li (ORCID: https://orcid.org/0000-0003-4419-062X)
- Hao Li
- Longhua Yang
- Hong Yao
- Wenjun Li
- Xiang-Dang Du
Institutions
- Ministry of Education (NZ)
- Shanghai Jiao Tong University (CN)
- Ministry of Agriculture (ID)
- Ministry of Agriculture and Rural Affairs (CN)
- Ministry of Agriculture (TN)
- Henan Agricultural University (CN)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1093/jac/dkag047
- Primary Topic
- Salmonella and Campylobacter epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00