miR-23b-3p deficiency exacerbates immune dysregulation in immunoglobulin A vasculitis by enhancing TLR4-mediated dendritic cell activation
miR-23b-3p regulates DC maturation and function and subsequent Tfh differentiation in a TLR4-dependent manner. miR-23b-3p deficiency aggravates IgAV by promoting pathogenic DC-Tfh axis activation, whereas restoration of miR-23b-3p expression attenuates immune dysregulation, suggesting a potential therapeutic strategy for IgAV.
Authors
- Jie Qiao (ORCID: https://orcid.org/0000-0003-2126-1376)
- Xiaoyu Jia
- Y. Ma
- Gang Luo (ORCID: https://orcid.org/0000-0002-0487-2311)
- Xiaoxue Ma
- Seunghyun Lee (ORCID: https://orcid.org/0000-0003-1858-0640)
- Yu Shan
- Jieqing Zhou
- Zhenshi Li
- Liang Zhang
Institutions
- Shenyang Medical College (CN)
- First Hospital of China Medical University (CN)
- Shenyang 242 Hospital (CN)
- Pusan National University (KR)
- China Medical University (CN)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2026-03-07
- DOI
- https://doi.org/10.1093/rheumatology/keag117
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00