Branched Schrödinger Bridge Matching.
Predicting the intermediate trajectories between an initial and target distribution is a central problem in generative modeling. Existing approaches, such as flow matching and Schrödinger bridge matching, effectively learn mappings between two distributions by modeling a single stochastic path. However, these methods are inherently limited to unimodal transitions and cannot capture <i>branched</i> or <i>divergent</i> evolution from a common origin to multiple distinct modes. To address this, we introduce <b>Branched Schrödinger Bridge Matching (BranchSBM)</b>, a novel framework that learns branched Schrödinger bridges. BranchSBM parameterizes multiple time-dependent velocity fields and growth processes, enabling the representation of population-level divergence into multiple terminal distributions. We show that BranchSBM is not only more expressive but also essential for tasks involving multi-path surface navigation, modeling cell fate bifurcations from homogeneous progenitor states, and simulating diverging cellular responses to perturbations.
Authors
- Pranam Chatterjee (ORCID: https://orcid.org/0000-0003-3957-8478)
- Siqi Tang (ORCID: https://orcid.org/0000-0001-6023-7294)
- Yinuo Zhang (ORCID: https://orcid.org/0000-0001-8956-7334)
- Alexander Tong
Institutions
- Duke-NUS Medical School (SG)
- University of Pennsylvania (US)
- Voith (United States) (US)
Publication Details
- Journal
- PubMed
- Published
- 2026-03-02
- Primary Topic
- Generative Adversarial Networks and Image Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00