High prevalence of loss of Claudin‐18 expression in invasive non‐mucinous lung adenocarcinoma: Potential diagnostic implications in routine practice
Cldn18 loss is a promising diagnostic biomarker for NM-LUAD. Complete loss of Cldn18 expression could serve as an ancillary tool for distinguishing malignant lesions from NM-LUAD mimickers and for differentiating NM-LUADs with mucin production from true M-LUADs, particularly in small or challenging biopsies.
Authors
- Beatrice Leonardi (ORCID: https://orcid.org/0000-0002-5595-6849)
- Riccardo Monti (ORCID: https://orcid.org/0000-0002-1003-3629)
- Floriana Morgillo (ORCID: https://orcid.org/0000-0002-9167-323X)
- Maria Giulia Disanto
- Luisella Righi (ORCID: https://orcid.org/0000-0002-8927-204X)
- Mario Fordellone (ORCID: https://orcid.org/0000-0003-0790-892X)
- Renato Franco (ORCID: https://orcid.org/0000-0002-8340-3184)
- Giuseppa Zannini
- Maria Ali
- Gaetano Di Guida
- Valerio Nardone (ORCID: https://orcid.org/0000-0002-7347-0965)
- Alfonso Fiorelli (ORCID: https://orcid.org/0000-0002-0628-613X)
- Severo Campione (ORCID: https://orcid.org/0000-0001-8414-8333)
- Mattia Barbareschi (ORCID: https://orcid.org/0000-0003-0217-3223)
- Marina Accardo
- Stefano Lucà
- Marco Montella
- Carminia Maria Della Corte
- Luka Brcic
Institutions
- Medical University of Graz (AT)
- Graz University Hospital (AT)
- Fatebenefratelli Hospital (IT)
- Provincia Autonoma di Trento (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Azienda Ospedaliera Universitaria Università degli Studi della Campania Luigi Vanvitelli (IT)
- University of Turin (IT)
Publication Details
- Journal
- Histopathology
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1111/his.70137
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00