Identification of COL4A2 as a Biomarker of Extracellular Matrix Remodeling and Vascular Scaffold in Choroid for Myopia
Type IV collagen is a key ECM in construction of the choroidal vascular lumen. COL4A2 is downregulated in FDM choroid, and suppression of COL4A2 impairs the choroid vascular scaffold and promotes myopia shift with decreased choroidal thickness.
Authors
- Z. Y. Zhang
- Yan Ni (ORCID: https://orcid.org/0000-0003-1779-7266)
- Bangjun Chen (ORCID: https://orcid.org/0009-0000-8657-5347)
- Yayun Xu (ORCID: https://orcid.org/0000-0002-8588-572X)
- Xiang Zhou (ORCID: https://orcid.org/0000-0002-4904-4245)
- Lin Wang
- Songlin Xie
- Chendong Yuan
Institutions
- Sun Yat-sen University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1167/iovs.67.3.31
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00