OmpK35 and OmpK36 Deficiencies Driving High-level Carbapenem Resistance in ST11 <i>Klebsiella Pneumoniae</i>
OmpK35 deficiency and OmpK36 structure alteration, combined with KPC-2 carbapenemase production, contribute to the high-level carbapenem resistance observed in ST11 CRKP strains. OmpK36GD represents an optimal model for OmpK36 deficiencies due to its minimal fitness cost. With the porin deficiencies, ST11 CRKP strains demonstrate enhanced growth and proliferation under carbapenem selection pressure, likely promoting their prevalence.
Authors
- Yongqiang Yang (ORCID: https://orcid.org/0000-0003-1554-3828)
- Alan McNally (ORCID: https://orcid.org/0000-0002-3099-630X)
- Ye Feng (ORCID: https://orcid.org/0000-0002-6551-1560)
- Jiayuan Qin (ORCID: https://orcid.org/0000-0002-5280-1657)
- Zhiyong Zong
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- University of Birmingham (GB)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1093/infdis/jiaf621
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00