Genetic and clinical determinants of tacrolimus accumulation in early liver transplantation: evidence for a combined genotype-antibiotic effect
These findings highlight a combined effect of genetic background and antibiotic use on tacrolimus trough exposure dynamics, providing mechanistic insight that may inform individualized monitoring and dosing in the early phase after liver transplantation.
Authors
- X. Li
- Zhuo Feng (ORCID: https://orcid.org/0000-0002-7311-5576)
- Xinfeng Cai (ORCID: https://orcid.org/0000-0003-0809-7102)
- Jinlin Guo (ORCID: https://orcid.org/0000-0001-8756-1190)
- Shiying Feng
- Jinyan Yang
- Rui Zhang
Institutions
- Shanxi Medical University (CN)
- Second People 's Hospital of Jinzhong (CN)
- Shanxi Provincial Cancer Hospital (CN)
- First Hospital of Shanxi Medical University (CN)
- Cancer Hospital of Chinese Academy of Medical Sciences (CN)
- Beijing Friendship Hospital (CN)
- Shanxi Provincial Children's Hospital (CN)
- Shanxi Provincial People’s Hospital (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1080/07853890.2026.2643032
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00