Residual Absolute Volume of Blastema as a Predictor of Clinical Outcomes in Patients With Wilms Tumor: A Report From the SIOP WT 2001 Study
AVB after preoperative chemotherapy is a strong, independent predictor of both EFS and OS in WT across risk groups. An AVB of ≥20 mL identifies a clinically relevant subset of patients with IRWT who may benefit from intensified therapy with doxorubicin. These findings support the use of AVB as a stratification criterion in future SIOP-RTSG protocols.
Authors
- Gema Ramirez-Villar
- Filippo Spreafico (ORCID: https://orcid.org/0000-0002-5587-3509)
- Norbert M. Graf (ORCID: https://orcid.org/0000-0002-2248-323X)
- Harm van Tinteren (ORCID: https://orcid.org/0000-0002-4626-8702)
- Nils Welter (ORCID: https://orcid.org/0000-0001-9874-4726)
- Hervé J. Brisse (ORCID: https://orcid.org/0000-0003-2794-5875)
- Rhoikos Furtwängler (ORCID: https://orcid.org/0000-0002-1967-8343)
- Arnauld Verschuur (ORCID: https://orcid.org/0000-0003-1070-4442)
- Beatriz de Camargo (ORCID: https://orcid.org/0000-0002-5794-1042)
- Jesper Brok (ORCID: https://orcid.org/0000-0003-2576-0228)
- Tanzina Chowdhury (ORCID: https://orcid.org/0000-0003-3891-5778)
- Rana Dandis
- C. Vokuhl
- Patrick Melchior
- Steven Walter Warmann (ORCID: https://orcid.org/0000-0001-5522-3250)
- Manfred Gessler (ORCID: https://orcid.org/0000-0002-7915-6045)
- M M van den Heuvel-Eibrink
- JP Schenk
- Leo Kager
- Jan Godzinski
- Gordan Vujanic
- Aurore Coulomb-L’Hermine
Institutions
- University of Bonn (DE)
- Utrecht University (NL)
- Heidelberg University (DE)
- University Hospital Bonn (DE)
- Great Ormond Street Hospital (GB)
- University Hospital of Bern (CH)
- Istituto Giannina Gaslini (IT)
- University Hospital Heidelberg (DE)
- Rigshospitalet (DK)
- Wroclaw Medical University (PL)
- Sorbonne Université (FR)
- Hôpital Armand-Trousseau (FR)
- Assistance Publique Hôpitaux de Marseille (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Comprehensive Cancer Center Mainfranken (DE)
- St Anna Children's Hospital (AT)
- Princess Máxima Center (NL)
- Instituto Nacional de Câncer - INCA (BR)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Hospital Universitario Virgen del Rocío (ES)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Wilhelmina Children's Hospital (NL)
- Hôpital de la Timone (FR)
- University College London (GB)
- Charité - Universitätsmedizin Berlin (DE)
- Institut Curie (FR)
- Saarland University (DE)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1200/jco-25-01755
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 0.00