Primary Hepatic Melanoma: A Case Report

Primary melanoma of the liver is very rare, with only a few cases reported. We present a 69-year-old patient with no significant medical history, admitted for the discovery of hepatic nodular lesions whose radiological examination suggested hepatocellular carcinoma. The biopsy of the nodular lesion revealed an undifferentiated malignant tumor, and immunohistochemical analysis using anti-SOX10, anti-Melan A, and anti-HMB45 antibodies confirmed melanocytic origin. Subsequently, the patient underwent additional examinations to search for the primary site, which were negative. Ultimately, the diagnosis of a primary melanoma of the liver was established.