Efficacy and Tolerability of Topotecan/Cyclophosphamide/Dinutuximab in Relapsed and Refractory High‐Risk Neuroblastoma: A Multi‐Institutional Retrospective Study
T/C/DIN is an effective regimen for patients with r/r HRNB, producing ORRs similar to prior reports in chemoimmunotherapy-naïve patients treated with I/T/DIN. Prior chemoimmunotherapy response may predict response to T/C/DIN, but even patients who progress while receiving I/T/DIN may benefit from the T/C/DIN combination.
Authors
- Elizabeth Sokol (ORCID: https://orcid.org/0000-0002-1787-6901)
- Rajen J. Mody (ORCID: https://orcid.org/0000-0001-5574-1779)
- Holly J. Meany (ORCID: https://orcid.org/0000-0002-2230-8351)
- Araz Marachelian (ORCID: https://orcid.org/0000-0003-3857-4782)
- Keri A. Streby (ORCID: https://orcid.org/0000-0002-2469-2553)
- Ami Vijay Desai (ORCID: https://orcid.org/0000-0001-9658-3156)
- Rochelle Bagatell (ORCID: https://orcid.org/0000-0002-5729-8819)
- Sara Michele Federico (ORCID: https://orcid.org/0000-0002-5807-4876)
- Benjamin Lerman (ORCID: https://orcid.org/0000-0001-9973-6779)
- Meaghan Granger (ORCID: https://orcid.org/0000-0002-5500-0927)
- Margaret E. Macy (ORCID: https://orcid.org/0000-0001-6446-9180)
- Jennifer H. Foster (ORCID: https://orcid.org/0000-0002-2126-9768)
- Madeleine King (ORCID: https://orcid.org/0009-0003-1765-2523)
- Thomas F. Cash (ORCID: https://orcid.org/0000-0002-1128-784X)
- Suzanne Shusterman (ORCID: https://orcid.org/0000-0002-5988-1792)
- Chelsee Greer
- Kieuhoa T. Vo
- Sara‐Jane Onyeama
Institutions
- University of Southern California (US)
- St. Jude Children's Research Hospital (US)
- Nationwide Children's Hospital (US)
- Children's Hospital of Philadelphia (US)
- Children's Hospital of Los Angeles (US)
- University of Chicago (US)
- Cook Children's Medical Center (US)
- Children's Hospital Colorado (US)
- Center for Cancer and Blood Disorders (US)
- Lurie Children's Hospital (US)
- UCSF Benioff Children's Hospital (US)
- Children's Healthcare of Atlanta (US)
- Texas Children's Hospital (US)
- C. S. Mott Children's Hospital (US)
- Dana-Farber/Boston Children's Cancer and Blood Disorders Center (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- University of Colorado Denver (US)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1002/1545-5017.70195
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00