Group 4 Medulloblastomas of Early Childhood Treated With High‐Dose Chemotherapy‐ and Craniospinal Irradiation‐Sparing Approach
High dose chemotherapy for Group 4 MB was associated with a relapse rate of 52.6%, which favorably compares to data reported with conventional chemotherapy. Salvage radiotherapy retrieved more than two-thirds of the patients. Half of the survivors never received radiotherapy. Such an approach may represent an alternative to upfront CSI for young children with Group 4 MB.
Authors
- Ashley Margol (ORCID: https://orcid.org/0000-0002-3038-8005)
- Juliette Hukin (ORCID: https://orcid.org/0000-0002-8727-8456)
- Natasha Pillay‐Smiley
- Kathleen Doris
- Virginia L. Harrod
- Rebecca J. Ronsley (ORCID: https://orcid.org/0000-0003-3961-3042)
- Patricia C. Orduña
- Lucie Lafay‐Cousin (ORCID: https://orcid.org/0000-0003-4569-3499)
- Ralph Salloum (ORCID: https://orcid.org/0000-0001-9437-0616)
- George Michaiel (ORCID: https://orcid.org/0000-0002-7817-9085)
- Akanksha Senapati
- Dolly Aguilera (ORCID: https://orcid.org/0000-0001-9668-8177)
- Astrid Bracher (ORCID: https://orcid.org/0000-0003-3025-5517)
- Susan Chi (ORCID: https://orcid.org/0000-0001-7753-878X)
- Claire Mazewski (ORCID: https://orcid.org/0000-0001-6970-0994)
- Andrew Cluster (ORCID: https://orcid.org/0000-0001-8963-7099)
- Martin Mynarek (ORCID: https://orcid.org/0000-0003-3302-2719)
- Lindsey M. Hoffman
- E. Bouffet
- Mohamed Shebl Abdelbaki (ORCID: https://orcid.org/0000-0002-8262-7469)
- Erin Ratterman
- Mary Pat Schlosser
- Vanan Magimairajan
- Vicente Santa‐Maria Lopez
- Sameer Farouk Sait
- Craig Erker
- Vijay Ramaswamy
- Michal Zapotocky
- Sylvia Cheng
- Alvaro Lassaletta
- Rose Daynielle Cansanay
- Stefan Rutkowski
- Chantel Cacciotti
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Dalhousie University (CA)
- Hospital Sant Joan de Déu Barcelona (ES)
- St. Louis Children's Hospital (US)
- Memorial Sloan Kettering Cancer Center (US)
- Children's Hospital of Los Angeles (US)
- Universität Hamburg (DE)
- University of Toronto (CA)
- Charles University (CZ)
- London Health Sciences Centre (CA)
- Hospital for Sick Children (CA)
- Alberta Children's Hospital (CA)
- Philippine General Hospital (PH)
- CancerCare Manitoba (CA)
- Manchester University NHS Foundation Trust (GB)
- Children's Hospital Colorado (US)
- University Hospital in Motol (CZ)
- Dell Children's Medical Center of Central Texas (US)
- University Medical Center Hamburg-Eppendorf (DE)
- Seattle Children's Hospital (US)
- Center for Cancer and Blood Disorders (US)
- Hospital Infantil Universitario Niño Jesús (ES)
- SickKids Foundation (CA)
- Children's Healthcare of Atlanta (US)
- BC Children's Hospital (CA)
- Stollery Children's Hospital (CA)
- Dana-Farber/Boston Children's Cancer and Blood Disorders Center (US)
- Research Institute in Oncology and Hematology (CA)
- University of Colorado Denver (US)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1002/1545-5017.70181
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00