Resumption of Warfarin After Intracranial Hemorrhage in Patients With Mechanical Heart Valves: A Systematic Review and Meta‐Analysis
Withholding anticoagulation for up to 7 days after intracranial hemorrhage in patients with mechanical heart valves appears relatively safe. Hemorrhagic recurrence after resumption was more common than ischemic stroke during interruption. However, the included studies were observational and carried serious or critical risk of bias. Prospective multicenter studies, and ideally randomized trials, are needed to provide more definitive evidence.
Authors
- Sherri A. Braksick (ORCID: https://orcid.org/0000-0001-6257-1464)
- Tasnim Elgazzar (ORCID: https://orcid.org/0000-0001-8401-6314)
- Yash Verma (ORCID: https://orcid.org/0000-0003-0631-5436)
- Amra Sakusic (ORCID: https://orcid.org/0000-0001-5810-5292)
- Jennifer E. Fugate (ORCID: https://orcid.org/0000-0001-7479-6732)
- Eelco F. M. Wijdicks
- Maximiliano A. Hawkes
- Alejandro A. Rabinstein
- Sherief Ghozy
Institutions
- Alfaisal University (SA)
- WinnMed (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1161/jaha.125.041301
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00