Inversed impaired osteogenic activity in children with severe obesity due to MC4R deficiency compared to LEP and LEPR deficiency
Our data demonstrate that osteogenic activity (but not resorption activity) is differentially affected in children with complete genetic disruption of the leptin-signaling pathway. Children with MC4R deficiency showed higher osteogenic markers, but children with LEP and LEPR deficiencies showed the opposite. Our results support the usefulness of bone turnover biomarkers for the assessment and management of bone health in different types of obesity.
Authors
- Roohia Khanam (ORCID: https://orcid.org/0000-0001-6826-7471)
- Amélie Bonnefond (ORCID: https://orcid.org/0000-0001-9976-3005)
- Sharoon Hanook (ORCID: https://orcid.org/0009-0004-1043-8708)
- Qasim M. Janjua (ORCID: https://orcid.org/0000-0001-7896-8802)
- Attiya Haseeb
- Muhammad Arslan (ORCID: https://orcid.org/0000-0002-2797-8506)
- Philippe Froguel
- Jaida Manzoor
- Sadia Saeed
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Lille (FR)
- Forman Christian College (PK)
- Institut Pasteur de Lille (FR)
- National University of Science and Technology (ZW)
- Mayo Hospital (PK)
- Imperial College London (GB)
Publication Details
- Journal
- International Journal of Obesity
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1038/s41366-026-02047-w
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Agence Nationale de la Recherche
- Pakistan Academy of Sciences
- Conseil Régional Hauts-de-France
- Medical Research Council
- CHIST-ERA