Novel Marine Fungus-Derived Mycophenolic Acids That Inhibit Acute Myeloid Leukemia Cell Proliferation
Nine new mycophenolic acid derivatives, penicacids O-W (<b>1</b>-<b>9</b>), two first-time reported natural products (<b>10</b>, <b>11</b>), and five known compounds (<b>12</b>-<b>16</b>), were isolated from a marine-derived fungus <i>Penicillium senticosum</i> RCDB005 found in a South China Sea sediment sample. Their structures were determined using NMR, HRESIMS, and optical rotatory dispersion (ORD) spectra, electronic circular dichroism (ECD) calculations, X-ray crystallography, and modified Mosher's methods. Eight of these compounds were evaluated for anti-proliferative effects against nine human cancer cell lines and the IC<sub>50</sub> values ranged from nM to μM levels. Compounds <b>5</b>, <b>7</b>-<b>9</b> showed potent inhibition activity against MOLM-13 acute myeloid leukemia cells with IC<sub>50</sub> values between 0.13 and 1.13 μM.
Authors
- Lingbin Lin
- Yangrong Zhao
- Qian Li (ORCID: https://orcid.org/0000-0003-1300-3377)
- Mengdi Wang (ORCID: https://orcid.org/0000-0002-2101-9507)
- Wu Ruan
- Qi Peng (ORCID: https://orcid.org/0000-0003-4393-3719)
- Qianqian Shen
- Yunan Liu
- Yuan Li
- Junfeng Wang
- Yi Chen
- Guangli Deng
Institutions
- Chinese Academy of Sciences (CN)
- Institute of Oceanology (CN)
- South China Sea Institute Of Oceanology (CN)
- Shanghai Institute of Materia Medica (CN)
- Institute of Deep-Sea Science and Engineering (CN)
Publication Details
- Journal
- Marine Drugs
- Published
- 2026-03-13
- DOI
- https://doi.org/10.3390/md24030108
- Primary Topic
- Biochemical and Molecular Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wuhan University
- Wuhan University of Technology