Picalm coordinates clathrin-mediated endocytosis and actin remodeling during myogenesis
Picalm regulates skeletal muscle differentiation by supporting clathrin-mediated endocytosis and plasma membrane remodeling, thereby maintaining trafficking-dependent control of actin organization. Its expression is responsive to metabolic cues such as exercise and intermittent fasting. These findings reveal a novel molecular link between nutrient signaling and myogenesis, with implications for metabolic disease and muscle regeneration.
Authors
- Wenke Jonas (ORCID: https://orcid.org/0000-0002-3441-9200)
- Maximilian Kleinert (ORCID: https://orcid.org/0000-0002-8069-9055)
- H. Vogel (ORCID: https://orcid.org/0000-0003-0347-9347)
- Annette Schürmann (ORCID: https://orcid.org/0000-0002-4113-4377)
- Jasmin Gaugel (ORCID: https://orcid.org/0000-0002-8658-833X)
- Michael Ebner (ORCID: https://orcid.org/0000-0002-0170-7062)
- Christian Freund (ORCID: https://orcid.org/0000-0001-7416-8226)
- Markus Jähnert (ORCID: https://orcid.org/0000-0001-6459-7318)
- Thilo Speckmann (ORCID: https://orcid.org/0000-0001-7265-0879)
- Tim Julius Schulz (ORCID: https://orcid.org/0000-0002-8413-3972)
- Benno Kuropka (ORCID: https://orcid.org/0000-0001-5088-6346)
- Neele Haacke
- Niclas Rausch (ORCID: https://orcid.org/0009-0003-6957-2699)
- Cora Weigert
- Julia Rominger
- Francisco Garcia-Carrizo
Institutions
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- German Institute of Human Nutrition (DE)
- Heinrich Heine University Düsseldorf (DE)
- Freie Universität Berlin (DE)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1016/j.molmet.2026.102351
- Primary Topic
- Cellular transport and secretion
- Type
- article
- Field-Weighted Citation Impact
- 0.00