Nutritional-inflammatory indices optimize the diagnostic performance of FIB-4 for advanced fibrosis/cirrhosis in patients with benign liver disease
In scenarios prioritizing high sensitivity, FIB-4 alone is suitable. For high specificity, a sequential strategy (FIB-4 + 'PAR and PNI') is recommended. For balanced performance, a parallel strategy (FIB-4 + 'PAR or PNI') provides optimal feasibility.
Authors
- Jie Lu (ORCID: https://orcid.org/0000-0001-5306-003X)
- Jie Zhou (ORCID: https://orcid.org/0000-0001-6164-3649)
- daofeng yang
Institutions
- Tongji University (CN)
- Capital Medical University (CN)
- Beijing YouAn Hospital (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1080/07853890.2026.2639649
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00