The Candesartan Adjunctive Depression Trials—CADET
The CADET Trials examine the efficacy of candesartan in reducing depressive symptoms in both unipolar and bipolar depression, and whether its effects are mediated through the renin-angiotensin system. Candesartan is affordable, accessible, and well-tolerated. If effective, it could quickly be adopted into clinical practice as a new adjunctive medication for the treatment of these disorders.
Authors
- J. Kim
- A. A. NIERENBERG
- Elle Nguyen (ORCID: https://orcid.org/0000-0002-0128-9075)
- Sylvia Chu Lin (ORCID: https://orcid.org/0000-0003-3080-6841)
- Sarah Croce
- John Amerena (ORCID: https://orcid.org/0000-0003-3011-0836)
- Janardhanan C. Narayanaswamy (ORCID: https://orcid.org/0000-0002-4724-5836)
- Stella May Gwini (ORCID: https://orcid.org/0000-0002-0295-4575)
- Joel King (ORCID: https://orcid.org/0000-0003-2171-8321)
- Adam J. Walker (ORCID: https://orcid.org/0000-0002-5399-1245)
- Olivia Dean (ORCID: https://orcid.org/0000-0002-2776-3935)
- Mohammadreza Mohebbi (ORCID: https://orcid.org/0000-0001-9713-7211)
- Steven Moylan (ORCID: https://orcid.org/0000-0001-8901-6225)
- Lana J. Williams (ORCID: https://orcid.org/0000-0002-1377-1272)
- Cas Schrueder
- Malcolm Hopwood (ORCID: https://orcid.org/0000-0001-6004-4521)
- Jeremy Couper (ORCID: https://orcid.org/0000-0003-4215-0851)
- Alyna Turner (ORCID: https://orcid.org/0000-0001-7389-2546)
- Paul Cortissos
- Jon‐Paul Khoo (ORCID: https://orcid.org/0009-0006-1860-527X)
- Melanie M. Ashton (ORCID: https://orcid.org/0000-0001-6832-4157)
- Jessica Green (ORCID: https://orcid.org/0000-0002-1219-8910)
- Judy Hope
- Sammy Russell
- John Tiller
- Rebecca Corva
- Chee H. Ng
- Mary Lou Chatterton
- Gin S. Malhi
- Brisa S. Fernandes
- Michael Berk
- Andre F. Carvalho
- Trisha Suppes
- Selin Hikmet
- Lars Vedel Kessing
- Bradley Matthews
- Chun Hui J. Park
- Emily Moriarty
- Seetal Dodd
- Kurukula Sarangi Nanayakkara
Institutions
- University of Copenhagen (DK)
- The University of Sydney (AU)
- Barwon Health (AU)
- Deakin University (AU)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- VA Palo Alto Health Care System (US)
- Florey Institute of Neuroscience and Mental Health (AU)
- Geelong Hospital (AU)
- St Vincent Hospital (US)
- Royal North Shore Hospital (AU)
- The Alfred Hospital (AU)
- Massachusetts General Hospital (US)
- Orygen Youth Health (AU)
- Monash Alfred Psychiatry Research centre (AU)
- Eastern Health (AU)
- St Vincent’s Private Hospital Sydney (AU)
- Ballarat Health Services (AU)
- Copenhagen Prospective Studies on Asthma in Childhood (DK)
- St. Vincent Hospital (US)
- Melbourne Clinic (AU)
- Alfred Health (AU)
- National Institute of Mental Health (CZ)
- Grampians Health
- Monash University (AU)
- Stanford University (US)
Publication Details
- Journal
- Journal of Clinical Psychopharmacology
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1097/jcp.0000000000002156
- Primary Topic
- Electroconvulsive Therapy Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00