Differentiating scrub typhus meningitis from brucellar meningitis in children: A single-center retrospective study

Although scrub typhus meningitis and brucellar meningitis share considerable clinical overlap in children, serum ferritin and PCT levels may represent potential diagnostic signals for early differential diagnosis, warranting validation in larger prospective cohorts. High Ferritin levels or PCT levels may provide preliminary clues toward scrub typhus meningitis. Early recognition and targeted antimicrobial therapy are associated with favorable prognostic outcomes.

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Publication Details

Journal
PLoS neglected tropical diseases
Published
2026-03-13
DOI
https://doi.org/10.1371/journal.pntd.0014107
Primary Topic
Vector-borne infectious diseases
Type
article
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article

Differentiating scrub typhus meningitis from brucellar meningitis in children: A single-center retrospective study

Y. Wang, Qingping Tang, Haifeng Jin, Yin Li et al.
PLoS neglected tropical diseases
Vector-borne infectious diseases
article

Differentiating scrub typhus meningitis from brucellar meningitis in children: A single-center retrospective study

Y. Wang, Qingping Tang, Haifeng Jin, Yin Li, Ruonan li, Ying Zhu, Penghao Cui, Yan Guo, Yonghan Luo
article en

Abstract

Although scrub typhus meningitis and brucellar meningitis share considerable clinical overlap in children, serum ferritin and PCT levels may represent potential diagnostic signals for early differential diagnosis, warranting validation in larger prospective cohorts. High Ferritin levels or PCT levels may provide preliminary clues toward scrub typhus meningitis. Early recognition and targeted antimicrobial therapy are associated with favorable prognostic outcomes.

PLoS neglected tropical diseasesVol. 20(3)
Kunming University of Science and Technology (CN), Kunming Medical University (CN), First People's Hospital of Yunnan Province (CN), Kunming Children's Hospital (CN)
Peace, Justice and strong institutions
Openalex Percentile: Top 22%
Vector-borne infectious diseases
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