Development of a Diagnostic Autoantibody Assay to a Consensus Motif for the Risk Prediction of Epstein-Barr Virus–Related Multiple Sclerosis
We describe a test for MS signature autoantibodies that could be used to support MS diagnosis, prodromal research, and early interventions. The integration of this assay with other emerging biomarkers will advance progress toward a combined predictive risk score for MS.
Authors
- Sydney Quintana
- Samuel J. Pleasure (ORCID: https://orcid.org/0000-0001-8599-1613)
- Kelsey C. Zorn (ORCID: https://orcid.org/0000-0003-1227-2137)
- Richard Cuneo
- Akshay Sharathchandra
- Bruce Cree (ORCID: https://orcid.org/0000-0001-7689-2533)
- Michael R. Wilson (ORCID: https://orcid.org/0000-0002-8705-5084)
- Asritha Tubati (ORCID: https://orcid.org/0009-0003-5303-1214)
- Jie Zhou (ORCID: https://orcid.org/0000-0003-3208-9073)
- Aaron Bodansky (ORCID: https://orcid.org/0000-0001-8943-8233)
- Joseph J. Sabatino (ORCID: https://orcid.org/0000-0002-6804-7441)
- Greer Waldrop (ORCID: https://orcid.org/0000-0001-6408-2330)
- Joe DeRisi
- Ravi Dandekar (ORCID: https://orcid.org/0000-0002-2930-3043)
- James Asaki (ORCID: https://orcid.org/0000-0002-8201-6588)
- S L Hauser
- Colette M. Caspar (ORCID: https://orcid.org/0009-0008-6803-1600)
- Krista McCutcheon
- Sasha Gupta
- Mitchell T. Wallin
- and the UCSF ORIGINS/EPIC team
- Stacy J. Caillier
- Jorge Oksenberg
- Thomas T. Ngo
Institutions
- University of Maryland, Baltimore (US)
- University of California, San Francisco (US)
- Chan Zuckerberg Initiative (United States) (US)
- Multiple Sclerosis Center of Atlanta (US)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1212/nxi.0000000000200551
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00