Disease Progression in Arrhythmogenic Cardiomyopathy: A Cardiac Magnetic Resonance Longitudinal Study

MF and right ventricular systolic dysfunction emerge as independent predictors of arrhythmic risk in ACM. Serial CMR assessments demonstrate that structural progression is common, supporting the concept that ACM represents a dynamic rather than a static disease process. Patients carrying PKP2 variants may exhibit heightened susceptibility to exercise-related arrhythmic risk.Arrhythmogenic cardiomyopathy (ACM) is a heart condition that can lead to dangerous arrhythmias and structural remodeling. In this study, we followed one of the largest groups of ACM patients with repeated cardiovascular magnetic resonance (CMR) scans to better understand how the disease evolves and how exercise after diagnosis affects outcomes.