The MTH1 inhibitor TH287 sensitized Castration-Resistant Prostate Cancer cells to ionizing radiation therapy
Overall, TH287 exhibited potent radiosensitization effects for CRPC treatment, effectively killing tumor cells when administered alongside IR at 12 h after the initial drug treatment.
Authors
- Xingbang Hu
- Yifeng Mao
- Yuan Tian
- Mingqiu Hu
- Zhizhong Tang
Institutions
- Taizhou Municipal Hospital (CN)
- Boxing People's Hospital (CN)
- The Second Affiliated Hospital of Bengbu Medical College (CN)
- Wuzhou Red Cross Hospital (CN)
- Gaozhou People's Hospital (CN)
Publication Details
- Journal
- International Urology and Nephrology
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1007/s11255-026-05096-2
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00