Patterns of HIV-1 Viral Load Suppression and Drug Resistance During the Dolutegravir Transition: A Population-based Longitudinal Study

Viral suppression increased during the DTG-transition with minimal emerging intermediate/high-level resistance. Falling resistance among treatment-experienced PLHIV underscores the role of ART adherence in reducing viremia. The emergence of inS153Y justifies continued surveillance.

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Publication Details

Journal
Clinical Infectious Diseases
Published
2026-03-07
DOI
https://doi.org/10.1093/cid/ciag161
Primary Topic
HIV/AIDS drug development and treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Patterns of HIV-1 Viral Load Suppression and Drug Resistance During the Dolutegravir Transition: A Population-based Longitudinal Study

Rajeev Gupta, Robert Ssekubugu, George MacIntyre-Cockett, Caitlin Elizabeth Kennedy et al.
Clinical Infectious Diseases
HIV/AIDS drug development and treatment
article

Patterns of HIV-1 Viral Load Suppression and Drug Resistance During the Dolutegravir Transition: A Population-based Longitudinal Study

Rajeev Gupta, Robert Ssekubugu, George MacIntyre-Cockett, Caitlin Elizabeth Kennedy, Ronald Moses Galiwango, Nicholas Grayson, Alexandra Blenkinsop, Oliver Ratmann, Joseph Kagaayi, Michelle Moffa, Sikhulile M. Moyo, Marc Martín, Godfrey Kigozi, Steven James Reynolds, Lucie Abeler-Dorner, Oliver Laeyendecker, Aaron A R Tobian, M Kate Grabowski, Thomas C Quinn, Fred Nalugoda, Gertrude Nakigozi, Christophe Fraser, David Bonsall
article en

Abstract

Viral suppression increased during the DTG-transition with minimal emerging intermediate/high-level resistance. Falling resistance among treatment-experienced PLHIV underscores the role of ART adherence in reducing viremia. The emergence of inS153Y justifies continued surveillance.

Clinical Infectious Diseases
Centre for Human Genetics (GB), Harvard University (US), Johns Hopkins University (US), University of Cambridge (GB), Stellenbosch University (ZA), Johns Hopkins Medicine (US), Nuffield Orthopaedic Centre (GB), University of Oxford (GB), NIHR Imperial Biomedical Research Centre (GB), Rakai Health Sciences Program (UG), Africa Health Research Institute (ZA), National Institute of Allergy and Infectious Diseases (US), Botswana Harvard AIDS Institute Partnership (BW), Imperial College London (GB), University of Pretoria (ZA), Makerere University (UG)
Good health and well-being
Openalex Percentile: Top 24%
HIV/AIDS drug development and treatment
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