Association of White Matter Hyperintensities, Regional Brain Glucose Metabolism, and Cognitive Impairment in Aβ-Negative Patients
The effect of PWMHs on executive dysfunction was mediated by cortical hypometabolism, whereas memory dysfunction was directly driven by PWMHs. These findings suggest that incorporating <sup>18</sup>F-FDG PET with MRI may enhance diagnostic and therapeutic stratification in clinical trials for vascular cognitive impairment.
Authors
- Dongjin Seo (ORCID: https://orcid.org/0000-0002-4585-4689)
- Tae Joo Jeon (ORCID: https://orcid.org/0000-0002-7574-6734)
- Hee Joo Yoon
- Hyunkeong Lim
- Youngjun Jun
- M R Yun
- Hyunkyung Han (ORCID: https://orcid.org/0009-0006-2672-384X)
- Daesung Kim
- Sangwon Lee
- Seungbeom Seo
- Sangwoo Cho
- Yeo Jun Yoon
- Hyo Jung Seo
- Seongjin Kang
- Young-gun Lee
- Minjae So
- Dongwoo Kim
Institutions
- Gachon University (KR)
- Yonsei University (KR)
- Gachon University Gil Medical Center (KR)
- Inje University Ilsan Paik Hospital (KR)
- Gangnam Severance Hospital (KR)
- Hallym University Sacred Heart Hospital (KR)
Publication Details
- Journal
- Neurology
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1212/wnl.0000000000214772
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00