Reduced Susceptibility to Cefepime–Taniborbactam in Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Attributed to Penicillin-Binding Protein 3 Modifications

Although PBP3-mediated FEP-TAN resistance entails measurable fitness costs, especially under nutrient-limited conditions, PBP3 polymorphism surveillance should be incorporated into resistance monitoring.

Authors

B F Zhang
Ke Ma (ORCID: https://orcid.org/0000-0002-8780-7434)
Mingliang Cheng (ORCID: https://orcid.org/0000-0002-2525-3595)
Wei Xu
Quan Zhang
Xiaoxia Zhang
Zhiyong Zong

Institutions

Sichuan University (CN)
West China Hospital of Sichuan University (CN)
Affiliated Hospital of Guizhou Medical University (CN)

Publication Details

Journal: The Journal of Infectious Diseases
Published: 2025-08-30
DOI: https://doi.org/10.1093/infdis/jiaf463
Primary Topic: Antibiotic Resistance in Bacteria
Type: article
Field-Weighted Citation Impact: 0.00

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article

Reduced Susceptibility to Cefepime–Taniborbactam in Carbapenem-Resistant Klebsiella pneumoniae Attributed to Penicillin-Binding Protein 3 Modifications

B F Zhang, Ke Ma, Mingliang Cheng, Wei Xu et al.

Aug 30, 2025

The Journal of Infectious Diseases

Antibiotic Resistance in Bacteria

article

Reduced Susceptibility to Cefepime–Taniborbactam in Carbapenem-Resistant Klebsiella pneumoniae Attributed to Penicillin-Binding Protein 3 Modifications

B F Zhang, Ke Ma, Mingliang Cheng, Wei Xu, Quan Zhang, Xiaoxia Zhang, Zhiyong Zong

August 30, 2025article en

Abstract

The Journal of Infectious DiseasesVol. 233(Supplement_1)

Sichuan University (CN), West China Hospital of Sichuan University (CN), Affiliated Hospital of Guizhou Medical University (CN)

Openalex Percentile: Top 41%

Antibiotic Resistance in Bacteria

DOI Source OpenAlex

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Reduced Susceptibility to Cefepime–Taniborbactam in Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Attributed to Penicillin-Binding Protein 3 Modifications — B F Zhang, Ke Ma, et al. · The Journal of Infectious Diseases (2025) | TGRS Research Map | TGRS