Real-world comparison of enzalutamide and apalutamide in metastatic hormone-sensitive prostate cancer: a multi-institutional propensity score-matched analysis
In this real-world Japanese cohort, Enz and Apa plus ADT showed comparable PSA responses, TTCR, and OS after PSM; however, Apa was associated with shorter TTF and more frequent AE-related treatment discontinuation. Reduced-dose initiation was more common with Apa without apparent TTCR disadvantage. Given the limited number of events, these findings should be interpreted with caution.
Authors
- Hirofumi Morinaka
- Kiyoshi Takahara (ORCID: https://orcid.org/0000-0002-4766-2074)
- Kensuke Hirosuna (ORCID: https://orcid.org/0000-0002-9263-4929)
- Yuki Yoshikawa (ORCID: https://orcid.org/0000-0001-8834-5051)
- Kyosuke Nishio
- Shutaro Yamamoto (ORCID: https://orcid.org/0000-0002-3061-1617)
- Tsuyoshi Morita
- TAKUYA TSUJINO
- Kazumasa Komura (ORCID: https://orcid.org/0000-0001-5082-3054)
- Moritoshi Sakamoto (ORCID: https://orcid.org/0009-0000-2053-0058)
- Taizo Uchimoto (ORCID: https://orcid.org/0000-0002-5200-9053)
- Atsushi Ichihashi
- Heima Niigawa
- Kazutoshi Fujita
- Wataru Fukuokaya
- Takafumi Yanagisawa
- Kosuke Iwatani
- Sho Kakumae
- Kazuki Nishimura
- Haruhito Azuma
- Masanobu Saruta
- Saizo Fujimoto
- Keiichiro Mori
- Atsuhiko Yoshizawa
- Shunsuke Tsuduki
- Takahiro Kimura
- Yutaka Yamamoto
- Ryoichi Maenosono
- Fumihiko Urabe
- Teruo Inamoto
Institutions
- Jikei University School of Medicine (JP)
- Kawasaki Medical School (JP)
- Hamamatsu University School of Medicine (JP)
- Fujita Health University Hospital (JP)
- Osaka University of Pharmaceutical Sciences (JP)
- Kindai University (JP)
Publication Details
- Journal
- Japanese Journal of Clinical Oncology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1093/jjco/hyag042
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00