Gut microbiota and neurotransmitter metabolic profiling in a rat model simulating hypoactive sexual desire disorder
Gut microbial dysbiosis contributes to RCB (simulating human HSDD) in female rats via modulating prefrontal cortex neurotransmitter excitation-inhibition homeostasis, with Oscillibacter and Bacteroides as key functional genera. These findings provide preliminary preclinical evidence for the gut-brain axis in sexual behavior regulation and human HSDD pathogenesis.
Authors
- Qunshan Shen (ORCID: https://orcid.org/0000-0001-7435-0693)
- Guanjian Li
- Chao Wang
- Yunxia Cao
- Bing Song
- Cong Ma
Institutions
- Anhui University (CN)
- Anhui Medical University (CN)
- Health Commission of Anhui Province (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- The Journal of Sexual Medicine
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1093/jsxmed/qdag067
- Primary Topic
- Sexual function and dysfunction studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00