A Comparison of Detection Rates Between Ultrasound and Post‐Therapeutic I‐131 <scp>SPECT</scp> / <scp>CT</scp> for Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma

Ultrasound demonstrated superior detection of metastatic lymph nodes, identifying a substantial subset (32.7%) of RAI-refractory disease missed by SPECT/CT. SPECT/CT remains valuable for confirming RAI avidity and detecting occult functional disease. These findings support a combined imaging strategy according to the metastatic characteristics. The presence of microcalcifications and hypoechogenicity was an important sonographic predictor of malignancy, with Level VI being the most common and predictable site of metastatic involvement.

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Publication Details

Journal
Journal of Ultrasound in Medicine
Published
2026-03-13
DOI
https://doi.org/10.1002/jum.70226
Primary Topic
Thyroid Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
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article

A Comparison of Detection Rates Between Ultrasound and Post‐Therapeutic I‐131 SPECT / CT for Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma

Santhosh A. Upadhyaya, Qing Dong, Arun Upadhyaya, X Q Wei et al.
Journal of Ultrasound in Medicine
Thyroid Cancer Diagnosis and Treatment
article

A Comparison of Detection Rates Between Ultrasound and Post‐Therapeutic I‐131 SPECT / CT for Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma

Santhosh A. Upadhyaya, Qing Dong, Arun Upadhyaya, X Q Wei, Rui Sang, Lei Zhu
article en

Abstract

Ultrasound demonstrated superior detection of metastatic lymph nodes, identifying a substantial subset (32.7%) of RAI-refractory disease missed by SPECT/CT. SPECT/CT remains valuable for confirming RAI avidity and detecting occult functional disease. These findings support a combined imaging strategy according to the metastatic characteristics. The presence of microcalcifications and hypoechogenicity was an important sonographic predictor of malignancy, with Level VI being the most common and predictable site of metastatic involvement.

Journal of Ultrasound in Medicine
Tianjin Medical University Cancer Institute and Hospital (CN)
Openalex Percentile: Top 24%
Thyroid Cancer Diagnosis and Treatment
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