Surgical Outcomes of Prepectoral Two-Stage Breast Reconstruction in Patients Treated with Pembrolizumab or CDK4/6 Inhibitors

Pembrolizumab is a promising therapy for TNBC, but its association with increased seromas, major complications, and reoperations warrants further investigation. Use of CDK4/6 inhibitors was not associated with an increased risk of infection following tissue expander placement.

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Publication Details

Journal
Plastic & Reconstructive Surgery
Published
2026-03-13
DOI
https://doi.org/10.1097/prs.0000000000013032
Primary Topic
Advanced Breast Cancer Therapies
Type
article
Field-Weighted Citation Impact
0.00
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article

Surgical Outcomes of Prepectoral Two-Stage Breast Reconstruction in Patients Treated with Pembrolizumab or CDK4/6 Inhibitors

Kelly McCann, M. Carter, Michael R. DeLong, Tahera Alnaseri et al.
Plastic & Reconstructive Surgery
Advanced Breast Cancer Therapies
article

Surgical Outcomes of Prepectoral Two-Stage Breast Reconstruction in Patients Treated with Pembrolizumab or CDK4/6 Inhibitors

Kelly McCann, M. Carter, Michael R. DeLong, Tahera Alnaseri, Neelesh Gupta, Anne Hall, Yasmine Ibrahim, M Demirjian, Lorna Kwan, Mediget Teshome
article en

Abstract

Pembrolizumab is a promising therapy for TNBC, but its association with increased seromas, major complications, and reoperations warrants further investigation. Use of CDK4/6 inhibitors was not associated with an increased risk of infection following tissue expander placement.

Plastic & Reconstructive Surgery
University of Southern California (US), University of California, Los Angeles (US), Los Angeles Medical Center (US)
Openalex Percentile: Top 23%
Advanced Breast Cancer Therapies
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