Testicular SIRT1 Loss Reveals an Aging‐Like Proteomic Landscape and Precipitates Reproductive Deterioration
Our findings indicate that partial loss of SIRT1 is sufficient to trigger proteomic and functional hallmarks of testicular aging. In particular, we identified specific proteomic signatures linked to subfertility, including the loss of key capacitation-related proteins regulated by SIRT1 in the testis, a pattern also observed in aged animals, which may represent a mechanistic model of SIRT1-governed fertilization failure.
Authors
- Milena Králíčková (ORCID: https://orcid.org/0000-0003-1907-4774)
- Jiřina Havránková
- Martin Knytl (ORCID: https://orcid.org/0000-0002-6325-6957)
- František Liška (ORCID: https://orcid.org/0000-0002-9588-806X)
- Hedvika Řimnáčová (ORCID: https://orcid.org/0000-0002-4375-2902)
- María Iniesta‐Cuerda (ORCID: https://orcid.org/0000-0002-2802-1925)
- Jan Nevoral (ORCID: https://orcid.org/0000-0002-2048-7325)
- Jiřı́ Moravec (ORCID: https://orcid.org/0000-0002-7359-5653)
Institutions
- Charles University (CZ)
- McMaster University (CA)
Publication Details
- Journal
- Andrology
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1111/andr.70201
- Citations
- 1
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 27.18