Theorem of inevitable death: calibration of the universal dissipative metabolism model on human ATP synthase

This work presents an experimental calibration of a universal dissipative metabolism model describing the dynamics of three fundamental state parameters — resource m, variability g, and consolidation k. The model is based on the concept of a metabolic power quantum P as an atomic portion of negentropy flow and includes theorems on inevitable death, survival criterion, and fluctuation spectral density isomorphic to Planck's formula. Based on structural data of human ATP synthase (EMDB ID EMD-34572, PDB ID 8H9L) and modern biophysical studies, empirical calibration of key parameters was performed: reinvestment efficiency, variability constant, quantum energy. The characteristic frequency of the fluctuation spectrum was obtained, corresponding to the mid-IR range. E. Schrodinger's principle (1944) on the suppression of quantum fluctuations in large molecular aggregates is quantitatively confirmed: it is shown that the isolated c-ring reaches the theoretical quantum rotation limit, but within the whole enzyme, rotation slows down by 1–3 orders of magnitude due to collective effects. The obtained values can be directly substituted into the model's dynamic equations for quantitative modeling of evolutionary, biological, and social processes.