The Effect of Pharmaceutical Excipients on Protein Chemical Degradation Through Deamidation and Isomerization
These results demonstrate how excipient-induced structural changes affect chemical degradation of proteins in liquid formulations. This study contributes to the understanding and design of more effective formulations for therapeutic proteins, enhancing their stability and safety.
Authors
- Johanna Hjalte (ORCID: https://orcid.org/0000-0002-2375-8856)
- Herje Schagerlöf (ORCID: https://orcid.org/0000-0003-1048-5059)
- Marie Wahlgren (ORCID: https://orcid.org/0000-0002-1705-3964)
- Ingrid Ramm (ORCID: https://orcid.org/0000-0002-8724-0861)
- Carl Diehl (ORCID: https://orcid.org/0000-0002-0959-6459)
- Amanda Västberg
- Lars Nilsson
Institutions
- Lund University (SE)
- Novo Nordisk (Denmark) (DK)
- RISE Research Institutes of Sweden (SE)
- SARomics Biostructures (Sweden) (SE)
- MAX IV Laboratory (SE)
Publication Details
- Journal
- Pharmaceutical Research
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1007/s11095-026-04040-4
- Primary Topic
- Protein purification and stability
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Lunds Universitet